Efficacy of Different Doses of Magnesium Sulphate Nebulization in Preventing Postoperative Sore Throat: A Comparative Study

doi:10.5281/zenodo.8346447

International Journal of Medical and Pharmaceutical Research

2023, Volume-4, Issue-5 doi: 10.5281/zenodo.8346447

Original Article

Efficacy of Different Doses of Magnesium Sulphate Nebulization in Preventing Postoperative Sore Throat: A Comparative Study

Dr Vandana V

Dr Apoorva Gupta

Dr Poornima Shivanna

Dr P Saraswathi Devi

DOI : 10.5281/zenodo.8346447

Published

Sept. 14, 2023

Abstract

Introduction: Postoperative sore throat (POST) is one of the most common complications in patients undergoing endotracheal intubation for general anaesthesia. Magnesium sulphate nebulization helps in providing equal and effective distribution of the drug throughout the pharynx and upper respiratory tract. In this study, we have compared three different strengths of magnesium sulphate (125 mg,250 mg and 500 mg) pre-operatively to prevent POST.

Methodology: A prospective randomized, comparative study of 90 physical status ASA Class I and II patients scheduled for surgeries under general anaesthesia requiring endotracheal intubation was conducted at a tertiary care hospital.

After institutional ethical committee clearance, informed written consent was obtained from all patients who met the inclusion criteria. Patients were randomized into group A (125mg MgSO4), group B (250 mg MgSO4) and group C (500mg MgSO4) according to sealed envelope method.

Patients included in the study were nebulized with respective doses of magnesium sulphate for 15 minutes before induction of anaesthesia. After the completion of surgery, patients were shifted to post operative anaesthesia care unit and incidence of postoperative sore throat at rest and on swallowing was assessed at 0, 2, 4 ,12 and 24 hours postoperatively.

Results: Incidence of POST at rest and swallowing was high in group A(125mg) at all time points. There was a statistically significant difference at rest between group A(125mg) and group C(500mg) at 0 hours (p= 0.015), 2 hours (p= 0.013), 4hrs (p=0.006),12hrs(p=0.005) & 24hrs(p=0.023).

No incidence of POST at rest was observed at 24hrs with Group C (500mg).

Incidence of POST at swallowing observed was statistically significant between group A(150mg) and group C(500mg) at all time points.

No significant difference was observed at both rest and swallowing between group B(250mg) and C(500mg) at all time points.

Conclusion: We conclude that 500mg MgSO4 nebulization administered pre-operatively is superior in attenuating the incidence of POST when compared to 250mg and 125mg.

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