Introduction: Laryngoscopy is performed to facilitate tracheal intubation which is a day to day routine in the practice of anaesthesiology. Both laryngoscopy and intubation are associated with physiological response such as sympathoadrenal response inducing tachycardia and hypertension. Aim: To study the effects of intravenous clonidine and intravenous dexmedetomidine in attenuation of hemodynamic response to direct laryngoscopy and tracheal intubation. The objectives of the study are: to compare hemodynamic changes of intravenous clonidine and intravenous dexmedetomidine among patients undergoing direct laryngoscopy and tracheal intubation in elective surgeries under general anaesthesia and to observe any adverse drug reactions. Materials and methods: This study was a hospital based observational study carried out in Jorhat Medical College and Hospital during July 2020 to June 2021.90 patients were divided alternatively into two groups. Result: Statistically significant difference in mean heart rate was observed at during laryngoscopy and intubation and at time 1 minute after laryngoscopy. A statistically significant difference was observed in mean systolic blood pressure between the two groups at time of laryngoscopy and intubation and at all times following intubation. Mean diastolic blood pressure had significantly difference during laryngoscopy and intubation and at all times following intubation. Mean of mean arterial pressure had statistically significant difference in both the groups at all observations following intubation. Conclusion: Both clonidine 1 mcg/kg and dexmedetomidine 1 mcg/kg attenuated the hemodynamic response to laryngoscopy and intubation but dexmedetomidine is a better choice than clonidine in attenuating the hemodynamic response to direct laryngoscopy and intubation.