Background and Objective: Rhomboid muscle pain is a common condition that can significantly affect an individual's functional ability and quality of life. InstrumentAssisted Soft Tissue Mobilization (IASTM) and joint mobilization are therapeutic techniques that have garnered attention for their effectiveness in pain management. To assess the effectiveness of IASTM combined with Maitland scapulothoracic joint mobilization against other conventional physiotherapy in alleviating pain among patients suffering from rhomboid muscle pain. Methods: A total of 30 subjects with rhomboid muscle pain were randomly assigned to two groups: Group A received IASTM combined with Maitland mobilization, while Group B received conventional physiotherapy. Pain levels were assessed pre- and postintervention using the Visual Analog Scale (VAS) and Numerical Pain Rating Scale (NPRS). The paired t-test was utilized to analyze differences between pre- and postintervention scores within each group. Results: There was a marked improvement in both groups. For Group A, the VAS scores significantly decreased (t-statistic = 9.92, p-value = 1.03 times 10^{-7}, and NPRS scores reflected a marked improvement (t-statistic = 11.82, p-value = 1.14 times 10^{-8}, showing high efficacy of the combined intervention. Group B achieved considerable reductions both in VAS (t-statistic = 8.40, p-value = 7.68 times 10^{-7} ) as well as in NPRS score (t-statistic = 16.36, p-value = \1.60 times 10^{-10 }. All these prove the fact that treatment with conventional physiotherapy enhances pain management and also proved in the present analysis that it even outshines this benefit. Conclusion: The results of this study suggest that the combination of IASTM and Maitland mobilization is more effective than conventional physiotherapy alone in managing rhomboid muscle pain. These techniques may be added to clinical practice to facilitate better outcomes for patients who experience pain and functional limitations.