Background: Myocardial infarction (MI) has been the common cardiovascular emergency seen in the emergency department, becoming the leading cause of death due to cardiovascular disease in India. Several drugs are being prescribed in patients with myocardial infarction with varied success. Aims and Objectives: The aim of this study is to analyze and evaluate the prescription pattern and prescribing trends of drugs used in patients with MI according to the WHO core prescribing indicators Materials and Methods: This is a retrospective observational study that was carried out at a tertiary care teaching hospital i.e. Raichur Institute of médical sciences Raichur, India. The case record files of all the in patients of médicine department with a diagnosis of MI between January 2024 to May 2024 were retrieved from medical record section & data like name, age, sex, diagnosis, ongoing treatment detailed information on drugs were collected and analysed & rationality of prescriptions was evaluated by using the WHO core drug prescribing indicators Results : A total 91 patients satisfied the inclusion criteria and were chosen as study participants. Majority of patients were males (57%) and maximum patients were in the age group of 41-60 yr (48%). Average number of drugs per encounter was 9 in our study. Percentage of drugs prescribed by generic name was 48% & drugs prescribed from essential drug list was 91%. Percentage of encounters with antibiotics prescribed was 70% & injection prescribed was 100 %.  Most commonly prescribed drugs in our study were Aspirin (96%), Clopidogrel (92%), Ranitidine (80%), Atorvastatin (78%), Enoxaparin (70%), Ceftriaxone (57%), Paracetamol (46%), Isosorbide Dinitrate (38%), Ramipril (35%), Ondansetron (34%), streptokinase (33%). Conclusion: Drugs prescribed by generic name was 48% which was less & drugs prescribed from NEDL was 91% which was good in our study.