Background:
Type 2 diabetes mellitus (T2DM) is associated with chronic low-grade inflammation and oxidative stress. Biomarkers like ceruloplasmin, transferrin, and high-sensitivity C-reactive protein (hs-CRP) may offer diagnostic and prognostic value.

Objectives:
To evaluate serum levels of ceruloplasmin, transferrin, and hs-CRP in T2DM patients and analyze their correlation with glycemic parameters.

Methods:
A case-control observational study was conducted with 130 T2DM patients and 60 age- and sex-matched healthy controls. Fasting blood samples were analyzed for hs-CRP, ceruloplasmin, transferrin, fasting glucose, and HbA1c. Statistical analysis included unpaired t-tests, Pearson correlation, and ROC curve analysis.

Results:
T2DM patients showed significantly elevated hs-CRP (p<0.001) and ceruloplasmin (p<0.01), and decreased transferrin levels (p<0.01) compared to controls. hs-CRP and ceruloplasmin positively correlated with HbA1c and fasting blood glucose, while transferrin showed an inverse correlation. ROC analysis demonstrated hs-CRP had the highest diagnostic accuracy (AUC: 0.84), followed by ceruloplasmin (0.77) and transferrin (0.71).

Conclusion:
hs-CRP, ceruloplasmin, and transferrin serve as accessible, cost-effective biomarkers reflecting inflammatory and oxidative stress status in T2DM. Their correlation with glycemic parameters underscores their potential utility in monitoring disease progression and risk stratification.