International Journal of Medical and Pharmaceutical Research
2025, Volume-6, Issue-3
Original Article
Detection Of Rubella Virus Antibodies In Women With Bad Obstetric History At A Tertiary Care Hospital In South Assam
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Published
June 30, 2025
Abstract

Rubella, a mild, self-limiting exanthematous disease characterised by fever, lymphadenopathy, rash. The etiologic agent Rubella virus is a positive sense ssRNA virus and a member of the family Matonaviridae. The teratogenic effects resulting in numerous undesirable pregnancy outcomes such as abortion, still birth, intra-uterine fetal death or congenital rubella syndrome (CRS), characterized by deafness, heart disease and cataract relates to its public health importance. Serology is the mainstay of diagnosis as typical clinical presentation is very rare. The present study was conducted on 120 women presenting with bad obstetric history.  All the serum samples were tested for Rubella-specific IgM antibodies by ELISA. A seropositivity of 10% was observed among cases with bad obstetric history. Within the test group, high sero-positivity (13.2%) was observed in women with repeated abortions followed by cases of intrauterine death (5.9%). The results indicate high prevalence of rubella in our population. Routine screening of antenatal cases is therefore necessary as early diagnosis will help in proper management and improve foetal outcome.

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