Polycystic Ovarian Syndrome (PCOS) is a metabolic syndrome affecting women’s reproductive health. PCOS is diagnosed using Rotterdam Criteria, and is often associated with insulin resistance. PCOS with insulin resistance (PCOS-IR) can both induce inflammation, in which the inflammation itself can worsen PCOS-IR. Moringa oleifera is a plant tested for its anti-inflammatory and anti-oxidant properties from pytochemicals that can be found in it. Aim: This research aims to study the effect of Moringa oleifera leaf extract administration to PCOS-IR rat models towards levels of C-reactive protein (CRP), a widely known biomarker of inflammation. Method: Female Wistar rats were divided into 3 groups (n=10): normal rats, PCOS-IR rats and PCOS-IR rats administered with 500 mg/kg Moringa oleifera leaf extract. PCOS rat model is created by injecting 1 mg / 100 gr testosterone proprionate for 21 days, and another 21 days for Moringa oleifera leaf extract administration. Blood is then collected and tested for CRP, and data collected will be statistically processed. Results: The PCOS-IR group showed increase in CRP level compared to control group, and the Moringa oleifera treated group showed significantly lower CRP level compared to PCOS group. The CRP level in Moringa oleifera treated group comes near to that of control group. Conclusion: Consumption of Moringa oleifera leaves can reduce inflammation in PCOS-IR shown by significant decrease of CRP levels.