There are innumerable variety of maxillofacial pathological diseases. In that some of them classically show the involvement of neck along with maxillo-mandibular region. Such disease entities need a special considerations since they may show impact on vital structures in the neck such as trachea, thyroid gland, great vessels, cranial nerves, cervical spine or vice-versa. In such conditions the oral and maxillofacial surgeon must be aware of the way of approaching the proper diagnosis in order to render better treatment along with multidisciplinary approach. This approach is needed in terms of not only diagnosis, but also in securing general anesthesia and performing surgical procedures, in which the neck plays a very crucial part. If any neck pathology is present along with maxillofacial region, it must be differentiated and appreciated thoroughly whether it is a combined or a separate entity of disease. Such approach broadens the treatment horizon for better treatment outcomes. A series of 10 such cases are presented within our clinical experience.