Correlation between Levels of Serum Gamma – Glutamy1 Transpeptidase(GGT) In Patients With Acute Myocardial Infarction and Its Potential As A Predictive Indicator

doi:10.5281/zenodo.10498224

International Journal of Medical and Pharmaceutical Research

2023, Volume-4, Issue-5 doi: 10.5281/zenodo.10498224

Original Article

Correlation between Levels of Serum Gamma – Glutamy1 Transpeptidase(GGT) In Patients With Acute Myocardial Infarction and Its Potential As A Predictive Indicator

Dr Vullangula Sai Avaneesh

Dr Poolla Srinivasa Rao

Dr Chanumolu Sri Varshini

Dr Sudulaguntla Dimple

Dr Raghavendra Sai Vetapalem

Dr Ballipalli Mohith

Dr Peddireddy Mounika

DOI : 10.5281/zenodo.10498224

Published

Oct. 31, 2023

Abstract

BACKGROUND: Gamma-glutamyl transferase (GGT) plays an important role of an enzyme responsible for breaking down glutathione, a vital antioxidant within mammalian cells.Coronary artery disease (CAD) stands as the primary reason of global mortality. Atherosclerosis stands as the primary factor behind Acute Coronary Syndrome (ACS)The pro-oxidant reactions facilitated by GGT subsequently accelerate LDL cholesterol oxidation, leading to peroxidation of lipids mainly LDL. This oxidative-stress brought about by GGT could potentially assume an important role in the formation of atheroma leading to atherosclerosis.

METHODOLOGY: The goal of this research is to measure the correlation amongst serum GGT levels in patients diagnosed with Acute Myocardial Infarction & to analyse how these levels relate to their medical outcomes.

RESULTS: In our analysis, a serum GGT level equal to or exceeding 52.5 U/L was identified as a predictor factor for coronary atherosclerosis with a significance level of P<0.022. The sensitivity of this predictor was found to be 72%, while the specificity was 71.4%.

CONCLUSION: GGT serves as a convenient, rapid, and effective marker of atherosclerosis. It provides insight into the extent of atherosclerosis among patients with myocardial infarction. Therefore, GGT can be employed as a supplementary marker for predicting atherosclerosis in individuals at risk

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