International Journal of Medical and Pharmaceutical Research
2024, Volume-5, Issue-6 doi: 10.5281/zenodo.133734600
Original Research Article
Contribution of CT Angiography and Doppler Ultrasound in Diagnosing Deep Vein Thrombosis in Patients with Pulmonary Embolism: A Prospective Study
Published
Nov. 9, 2024
Abstract

Background: The diagnostic accuracy of computed tomography venography (CTV) in detecting deep vein thrombosis (DVT) among pulmonary embolism (PE) patients remains an area of active investigation. Objectives: To evaluate the diagnostic performance of CTPA combined with indirect CTV in diagnosing DVT in PE patients and compare it with Doppler ultrasonography. Materials and Methods: This prospective cross-sectional study included 50 patients with suspected PE who underwent both CTPA with indirect CTV and Doppler ultrasonography. The study was conducted over 12 months using a 128-slice CT scanner and standardized ultrasound protocols. Results: The study population comprised 58% males and 42% females, with the majority (54%) aged 31-50 years. DVT was detected in 50% of cases by Doppler ultrasonography and 46% by CTV. CTV demonstrated sensitivity of 76.0%, specificity of 84.0%, positive predictive value of 82.6%, and negative predictive value of 77.8%. The area under the ROC curve was 0.800 (95% CI: 0.671-0.929), with substantial agreement between modalities (κ=0.600, p=0.0005). Right pulmonary artery involvement was most common (18%), and additional pathological findings were observed in 70% of cases. Conclusion: CTV shows substantial agreement with Doppler ultrasonography in DVT detection, offering the advantage of concurrent PE and DVT evaluation in a single examination. The high diagnostic accuracy supports its integration into routine PE imaging protocols.

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