Introduction: Tracheal extubation is the process of removing an endotracheal tube (ETT) from the trachea, typically after it has been used to assist with breathing during or after surgery. Injlidocaine and inj. Fentanyl are supposed to suppress the hemodynamic response to extubation during laparoscopic surgeries.

Objective: To compare the effect of i.v. lidocaine & i.v. fentanyl reduce the hemodynamic response to extubation for laparoscopic surgeries. Patients who were posted for laparoscopic surgeries from ASA I & II age between 18 and 60yrs. p-values of <0.05 were considered as statistically significant with power of 80%. In our study we used the Unpaired T test for the comparison of mean of heart rate & mean arterial B.P., Mann Whitney U test for the distribution of free data. Also chi square test for the analysis of association of categorical independent variables between two groups.

Results: The pulse rate and mean arterial blood pressure were significantly lower in inj fentanyl group at 1 min, 5 min, 10 min and 15 min after extubation with p-values <0.05. There was no significant difference between two groups with decreasing the incidence of coughing in peri- extubation period with p-value of 0.857.

Conclusion: The research of our study shows that Inj fentanyl 1 mcg/kg i.v. if administered 10 min before the end of operation was very effective in reducing the haemodynamic response to tracheal extubation compared with Inj lidocaine 1mg/kg i.v. in patien posted for laparoscopic surgeries. Recommendation We recommend that injfentanyl administered 10 min before the end of laparoscopic surgeries is effective in reducing haemodynamic response to extubation.