To compare the efficacy of tablet pregabalin (150 mg) and tablet gabapentin (600 mg) on post operative analgesia in elective laproscopic cholecystectomy under general anesthesia. Also secondarily compare the shoulder pain intensity, need for rescue analgesia and compare hemodynamic changes. It can be observed from the present study that the two groups were comparable for age, sex, weight and ASA status of the patients. It was observed that post-operative mean VAS score was significantly different at 4 hr (p value 0.002) and at 8 Hr (p value <0.001) when compared between the two groups. No significant difference in mean VAS score was observed for other time points.  It was concluded that pain score was significantly more in Group G at 4 hr and significantly lower at 8 hrs when compared to Group P.

It was observed that under group P, 88% of the patients had no shoulder pain while 12% had shoulder pain. Under group G, 78% of the patients had no shoulder pain while 22% had shoulder pain (p value 0.183)

It was observed that under group P, rescue analgesic was used in 12% & 88% of the patients after 4 hrs and 8 hrs respectively. Under group G. rescue analgesic was used in 34% & 66% of the patients after 4 hrs and 8 hrs, respectively. (p value <0.001)

Thus it was concluded from our study that pregabalin 150mg and gabapentine 600mg both are suitable and safer alternative for post operative pain management. However pregabalin provides better post operative analgesia