Background: Diabetic foot ulcers (DFUs) pose a significant challenge in diabetes care,with varying treatments available. This study compared the efficacy of Negative Pressure Wound Therapy (NPWT) with traditional dressings in DFUs management. Methods: A prospective, randomized comparative study was conducted involving 120
patients with DFUs, divided equally between NPWT and traditional dressings groups. The primary outcomes measured were healing time, wound healing rates at 4, 8, and 12 weeks, infection rates, and incidence of complications. Results: NPWT significantly reduced the mean healing time to 6.8 weeks compared to 9.5 weeks for traditional dressings (p < 0.001). Healing rates at 4, 8, and 12 weeks were significantly higher in the NPWT group (30%, 60%, and 78%, respectively) compared to the traditional dressings group (18%, 40%, and 58%, respectively) with p-values of 0.045, 0.03, and 0.023. The NPWT group also showed a lower infection rate (10% vs. 25%, p =
0.015) and fewer complications, including rates of gangrene (3.3% vs. 10%, p = 0.038) and amputation (1.7% vs. 8.3%, p = 0.042). Conclusion: NPWT offers significant advantages over traditional dressings in the management of DFUs, including faster healing, higher healing rates, reduced infection rates, and lower incidence of severe complications. These findings support the preference for NPWT in DFU treatment protocols, considering individual patient conditions.