Background: Rocuronium bromide is a widely used non-depolarizing neuromuscular blocking agent for endotracheal intubation. This study aimed to compare the intubating conditions and hemodynamic changes of three different doses of rocuronium bromide during endotracheal intubation.

Methods: This prospective observational study included 60 ASA I-II adult patients (25-45 years) undergoing elective abdominal surgeries, divided into three groups of 20 patients each: Group A (0.6 mg/kg), Group B (0.9 mg/kg), and Group C (1.2 mg/kg). Intubating conditions were assessed at 60 seconds after administration using Cooper's criteria. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were recorded before induction, after induction, and at 1, 3, and 5 minutes after intubation. Train-of-four (TOF) monitoring was used to assess neuromuscular blockade.

Results: Clinically acceptable intubating conditions (excellent or good) were observed in 0%, 45%, and 100% of patients in Groups A, B, and C, respectively (p<0.001). Mean intubating scores were 3.25±1.07, 5.20±1.67, and 8.35±1.18 in Groups A, B, and C, respectively (p<0.001). After intubation, hemodynamic parameters increased in all groups, with Group A showing the most significant changes (p<0.001). Mean time to loss of TOF was 123.60±3.27, 93.35±5.02, and 61.50±3.85 seconds in Groups A, B, and C, respectively (p<0.001).