Background:The increase in maternal mortality rates (MMR) is an occurrence that needs attention in Indonesia. According to Dinas Kesehatan Jawa Timur, 2019 the MMR in 2020 reached 98,39 per 100.000 live births, with approximately 26,9% or 152 individuals attributed to hypertension during pregnancy. Hypertension is diagnosed with systolic blood pressure reaches more than 140 mmHg and diastolic blood pressure is 90 mmHg. This condition becomes more concerning if hypertension develops after 20 weeks of pregnancy and is accompanied by proteinuria or other organ damage, known as preeclampsia. One of the strongest theory is the presence of uteroplacental ischemia and maternal infection, leading to an increase in pro-inflammatory cytokines (TNF-alpha and IL-6). Thus, it can be concluded that there is an increase in the inflammatory response at low levels. The presence of IL-6 induced the formation of C-Reactive Protein (CRP), a primary biomarker for inflammation if its value is > 0.3 mg/dl, requiring specific attention and appropriate management.

Methods: This study aims to determine the comparison of CRP levels in preeclamptic pregnant women with normal third-trimester pregnant women at Bhakti Dharma Husada Hospital in 2023. The research took place from October 2023 to November 2023. Patient characteristics were obtained through secondary data from patient medical records, and CRP data were obtained from laboratory test.

Results:The research, involving 20 pregnant women, found a significant difference using non-parametric Mann-Whitney test between the preeclampsia group and the normal third-trimester pregnant group (P<0,05).

Conclusions:This indicates that the occurrence of preeclampsia has an impact on increasing CRP.