Comparison between the Effects of Intravenous Dexmedetomidine and Magnesium Sulphate in Attenuation of Haemodynamic Response to Laryngoscopy in Laparoscopic Abdominal Surgery – A Two Arm Observation Study

doi:10.5281/zenodo.10057963

International Journal of Medical and Pharmaceutical Research

2023, Volume-4, Issue-5 doi: 10.5281/zenodo.10057963

Original Article

Comparison between the Effects of Intravenous Dexmedetomidine and Magnesium Sulphate in Attenuation of Haemodynamic Response to Laryngoscopy in Laparoscopic Abdominal Surgery – A Two Arm Observation Study

Dr Rina

Dr Dipro

Dr Goutam

DOI : 10.5281/zenodo.10057963

Published

Oct. 31, 2023

Abstract

Background: This study was conducted to evaluate the cardiovascular effects of DEXMED (dexmedetomidine) and MgSO4 (magnesium sulfate) in a clinical setting.

Methods: A total of 126 patients were equally distributed between two groups: DEXMED and MgSO4. Vital parameters, including heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), were assessed at various time points before and after drug administration.

Results: The DEXMED group consistently exhibited lower heart rates post-drug administration, with statistically significant differences at all measured time points (p<0.001). In terms of blood pressure, the DEXMED cohort revealed lower SBP, DBP, and MAP across all time intervals, with p-values ranging from 0.040 to 0.000. The mean age of the DEXMED group was 39.13 ± 9.48 years, while the MgSO4 group had a mean age of 37.30 ± 8.14 years (p=0.63).

Conclusion: DEXMED administration resulted in consistently lower heart rates and blood pressures compared to MgSO4. Given the cardiovascular implications, meticulous patient monitoring is paramount, especially in those with cardiovascular comorbidities. Personalized medical approaches in selecting anesthetic agents are advised.

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