Background: Acne vulgaris is a prevalent skin condition requiring effective treatment strategies. This study compares the efficacy and tolerability of topical Clindamycin alone versus a combination with Benzoyl Peroxide in treating mild to moderate acne.

Methods: A randomized study involving 200 participants compared Clindamycin alone (n=100) and Clindamycin combined with Benzoyl Peroxide (n=100). The primary outcome measures were total lesion count and Investigator Global Assessment (IGA) scores over 8 weeks. Adverse events and patient compliance were also evaluated.

Results: The combination therapy group showed a greater reduction in total lesion count (64.7% reduction) compared to the Clindamycin group (48.6% reduction) with a significant difference (p<0.001). IGA score improvement was also more substantial in the combination group (52.9% improvement) compared to the Clindamycin group (44.4% improvement, p=0.046). Adverse events were more frequent in the combination group but did not significantly affect compliance.

Conclusion: The combination of Clindamycin and Benzoyl Peroxide demonstrated superior effectiveness in treating mild to moderate acne compared to Clindamycin alone, with a higher but manageable rate of adverse events. These findings suggest that combination therapy can be a more effective option for acne management, balancing efficacy and tolerability.