Background and Aim: Airway difficulty is common in pregnancy than in the general population due to anatomical and physiological changes during pregnancy. Spinal anaesthesia in pregnant women is associated with greater incidence of having hypotension. Although glycopyrrolate has been investigated previously as an adjunctive agent for preventing hypotension during caesarean section, few data are available for its use specifically when phenylephrine is used as the primary vasopressor. Our study aims to determine the effectiveness of prophylactic combined glycopyrrolate and phenylephrine boluses in maintaining the haemodynamics as compared to prophylactic phenylephrine bolus alone during spinal anaesthesia in caesarean section. Method: A prospective, double-blinded clinical study was conducted in the Department of Anaesthesia in collaboration with the Department of Obstretrics and Gynaecology from June 2020 to July 2022. Ninety respondents undergoing cesarean section were allocated into two groups. Group A (n = 45) received prophylactic injection of bolus glycopyrrolate 0.2mg immediately after spinal anaesthesia followed by prophylactic bolus of phenylephrine 75 mcgs intravenously (IV) and Group B (n = 45) received prophylactic bolus of normal saline 1ml immediately after spinal anaesthesia and bolus of injection phenylephrine 75mcgs IV. Then, for every 3 min, systolic blood pressure, diastolic blood pressure, and heart rate (HR) were measured for 30 min, and APGAR scores were measured. Result: There was no difference between systolic pressure upto 6mins between the two groups. But from 9mins, lowering of blood pressure was recorded more in group B. For diastolic pressure, it was found to be significantly lower in Group B. However, maintenance of pulse rate was observed better in Group A. Conclusion: Incidence of bradycardia was found to be reduced in group A as compared to group B. Haemodynamic stability was found to be more in the group where prophylactic glycopyrrolate was used.