The purpose of this study was to assess the changes in the corneal endothelial cells of medical students and doctors who used soft hydrogel contact lenses for myopia correction during a three-month period. The study included 50 subjects, with 25 wearing contact lenses and the remaining participants wearing spectacles. The morphology of corneal endothelial cells in both groups was assessed using a specular microscope to determine endothelial cell density, coefficient of variation, hexagonality, and central corneal thickness. At baseline (p-value = 0.14) and 3 months (p-value = 0.07), there was no statistically significant difference in refraction between Group A (-2.460.96 diopters) and Group B (-2.831.55 diopters). Similarly, at baseline (p-value = 0.26) or 3 months (p-value = 0.96), there is no statistically significant difference in ECD between Group A (3108.19228.30 cells/mm2) and Group B (3012.53225.95 cells/mm2). Furthermore, p-values larger than 0.05 show no statistically significant difference in COV, HEX, or CCT between the two groups at either time point. The study concluded that the absence of change in corneal endothelial cell shape is most likely attributable to the contact lens material's good oxygen permeability, compliance, and short wearing period.