Introduction: Diabetic foot ulcers (DFUs) are a debilitating complication of diabetes mellitus, characterized by chronic non-healing wounds that may lead to hospitalization or amputation. Optimizing wound healing strategies is crucial to reduce morbidity. Platelet-rich plasma (PRP), rich in growth factors, has emerged as a novel therapeutic adjunct to promote wound healing.

Objective: This study compares the effectiveness of autologous PRP dressing versus conventional normal saline (NS) dressing in promoting wound healing among patients with diabetic foot ulcers.

Methods: A prospective randomized controlled study was conducted at the Department of Surgery, TMMC&RC, Moradabad, over 18 months. Seventy-four patients with diabetic foot ulcers (Wagner Grades 1–3) were randomized into two groups: Group A received PRP dressings; Group B received NS dressings. PRP was prepared via double centrifugation and applied weekly. Wound healing was assessed by reduction in ulcer size, granulation tissue formation, and duration of hospital stay.

Results: Patients in the PRP group demonstrated a statistically significant faster rate of wound healing compared to the NS group. On day 7, 100% of PRP patients showed granulation tissue versus 62% in the NS group. Mean healing time and hospital stay were significantly reduced in the PRP group. No adverse events were noted.

Conclusion: Autologous PRP dressing significantly accelerates wound healing in diabetic foot ulcers compared to normal saline. It is safe, easy to prepare, and cost-effective, offering a promising alternative for managing chronic wounds in diabetic patients