Background & Objective This comparative observational trial was carried out to establish the benefits of the 'Mandakini' dressing in comparison with conventional wet gauze dressings, in patients with neuropathic plantar ulcers. The objective of this study is: • To compare the effect of mandakini offloading technique over normal saline in diabetic foot ulcer. • To show the improvement in quality of ulcer healing using mandakini offloading technique. Methods Study Design - Hospital based Comparative Observational study. Period of study – 9 months from September 2021 to May 2022 Place of study: A. J. Institute of Medical Science and research Centre, Mangalore Sample size- Total of 50 patients are taken divided into two groups of 25 each. The treatment group received ‘Mandakini’ dressing which was changed every week. Control group received conventional normal saline dressings. Size of the ulcer, grade of the ulcer and wound surface area was assessed at the end of every week up to 6 weeks in both groups. The percentage of wound covered with granulation tissue, the percentage of wound covered with non-viable tissue and the time taken for healing of the ulcer were compared between the two groups Results: A total of 50 patients were randomized into treatment and control group with 25 patients in each. The ‘Mandakini’ dressing group had a significant reduction in the wound size compared to the control group). Time taken for healing of the ulcer was significantly less in ‘Mandakini’ dressing group Interpretation & Conclusion: Mandakini dressing significantly reduces the wound size and time taken for the healing of plantar ulcer compared to conventional normal saline dressing. Patient acceptability, patient satisfaction, quality of life and cost of the total treatment were better in Mandakini dressing group.