Background : Due to the widespread use of tobacco in India Head and Neck cancer (HNC) cases are on the rise and it account for 30% of all cancer cases, based on geographical locations usage patterns of tobacco. Despite being more common in males, research has shown that there are variations based on anatomical subsites.

Aim: The aim of the present study is to evaluate clinical presentation of Head and Neck malignancy among patients attending Agartala Government Medical College and their histopathological attributes would be analysed.

Methods and Materials: This is a hospital based prospective observational study of 96 cases consecutive biopsy proven HNC patients from a large comprehensive Tertiary care centre from Tripura during the period of September 2021 to 2022 December. Data collected for the study included age, gender, site of the disease, use of tobacco and histopathological characteristics. The categorical data were analysed by a chi square test using SPSS (version 22).

Results: In the present study, 42.7% of Head and Neck cancers were found in the age of 51-60 years with strong male preponderance (78%) compared to females (22%). Mostly patients were from rural (65%) backgrounds. The most common type of carcinoma is Squamous Cell Carcinoma (88%) and most common subsite involved are Supraglottis (21.9%). There is a strong and significant association found between use of tobacco and Head and Neck malignancies.

Conclusion: Most of Head and Neck malignancies are Squamous Cell Carcinoma and supraglottis and oral cavity were commonly involved. Commonly affected the age group of 40-60 years with male predominance. Strong correlations were observed between tobacco use and Head and Neck malignancy.