Introduction: The individuals with diabetes have at least a 10-fold greater risk for soft tissue and bone infections of the foot than individuals without diabetes. The Indian diabetic population is expected to increase up to 57 million by the year 2025.

Aims and Objectives: To evaluate the bacteriological profile and antibiogram of diabetic foot ulcer.

Material and Methods: 150 Samples of diabetic foot ulcers were collected over a period of six months by using sterile swabs and they were processed as per the standard protocol. Pathogenic organisms were isolated, identified by biochemical tests. Antibiotic susceptibility testing was done by Kirby -Bauer disk diffusion method on Mueller Hinton Agar and results were interpreted as per Clinical and Laboratory Standards Institute guidelines.

Results: Bacterial etiology could be identified among 74 cases out of 150 (49.3%), among which Pseudomonas aeruginosa was the commonest (in 25 cases), followed by Klebsiella spp. (in 20 cases), Escherichia coli (in 13 cases), Proteus mirabilis (in 12 cases), Staphylococcus aureus (in 3 cases) and Enterococcus in 1 case.

Conclusion: Gram negative bacilli were more prevalent 70 out of 74 cases (94.5%) than gram positive cocci, 4 out of 74 cases (5.5%). In our study the commonest isolate was Pseudomonas aeruginosa (33.7%), followed by Klebsiella spp. (27.02%) and Escherichia coli (17.56%). Meropenem and Piperacillin/tazobactam are drug of choice in such cases.