Background: Mucormycosis is a severe fungal infection that has seen a significant increase in cases, particularly among COVID-19 patients, posing a major challenge to healthcare systems in India. Understanding the clinical and epidemiological profile of mucormycosis patients is crucial for effective management and resource allocation a study was conducted to analyse the clinico-epidemiological profile of mucormycosis patients. Objective: The objective of this retrospective study was to examine the clinical and epidemiological profile of patients with mucormycosis admitted to RIMS Teaching Hospital. Materials & Methods: A retrospective study design was employed, utilizing existing records and documents from patients admitted to RIMS Teaching Hospital with a diagnosis of mucormycosis. Relevant data, including demographic information, medical history, treatment details, and outcomes, were extracted and analyzed. Data cleaning and quality assurance measures were implemented to ensure accuracy and reliability. Results: The study included 55 patients diagnosed with mucormycosis. The clinical and epidemiological profile of these patients was assessed, revealing important findings. Corticosteroid therapy was found to be commonly administered in the management of mucormycosis; however, the study highlighted the need for careful evaluation of the potential risks and uncertainties associated with its use. The prevalence rates of comorbidities differed from previous studies, emphasizing the association between COVID-19, diabetes mellitus, and mucormycosis, underscoring the importance of comprehensive strategies targeting these interconnected conditions. The distribution of affected anatomical sites reflected potential routes of fungal invasion, with notable variations observed. Furthermore, a significantly higher survival rate was observed among the patients, suggesting the potential effectiveness of the management approach employed. Conclusion: This retrospective study provides valuable insights into the clinical and epidemiological profile of patients with mucormycosis admitted to RIMS Teaching Hospital. Careful evaluation of corticosteroid therapy, comprehensive strategies addressing comorbidities, and understanding the distribution of affected anatomical sites are crucial for effective management and prevention. These findings contribute to our understanding of mucormycosis and provide a basis for future investigations and interventions.