BACKGROUND: Thrombocytopenia is a prevalent problem for physicians of many specialties in tropical areas such as India. In many etiological disorders, thrombocytopenia manifests as an asymptomatic condition that might progress to a life-threatening condition requiring blood transfusion. Malaria and dengue fever infections are generally linked with thrombocytopenia, with variable clinical patterns. The most prevalent cause of thrombocytopenia is infection. The aim of present study the clinical profile and outcome of patients presenting with severe thrombocytopenia.

METHODOLOGY: A prospective study was conducted in patients presented with severe thrombocytopenia in Dayanand Medical College and Hospital, Ludhiana from 1/03/2021 to 28/02/2022.The patients were followed up during their hospital stay and further followed up on OPD basis for 6 weeks or till the response was achieved..

RESULTS: Tropical fever was the most common cause of severe thrombocytopenia with 61 cases followed by sepsis with 23 cases. Bleeding manifestations were seen in 43.08% patients. Complete response was seen in 80% of the tropical fever, 43% of sepsis and 66% of ITP patients. Mortality was maximum in patients with sepsis induced thrombocytopenia.

CONCLUSION: Tropical fever is the commonest diagnosis made in patients who are detected to have severe thrombocytopenia. Treatment of the patients varied with the underlying etiology. Mortality was maximum in sepsis induced thrombocytopenia.