Background and Aim: The definition of acute organ dysfunction and infection, as well as the data sources used, influence the rates of sepsis and septic shock. This investigation was therefore carried out to highlight the relationship between morbidity and mortality and hyperuricemia in patients with clinically confirmed sepsis. Materials and Methods: The study included 150 patients in total. Blood samples were obtained from the patients in order to estimate their uric acid levels. The department of the biochemistry and medicine in RKDF Medical College Hospital & Research Center, Jatkhedi, Bhopal, Madhya Pradesh collaborated on the biochemical estimation of the uric acid level. Results: Of the 150 participants in the study, 64 patients (42.7%) had increased uric acid levels, whereas 86 patients (57.3%) had normal uric acid levels. It can be deduced that patients with type 2 diabetes mellitus were among the study population. 40% is the most prevalent comorbidity. Type 1 and type 2 diabetes, decompensated liver disease, and cerebrovascular accidents were the most common comorbidities among individuals with hyperuricemia. About 36% of research participants who had no comorbidities also experienced sepsis. Conclusion: This study shows that in patients with clinically confirmed sepsis in the intensive care unit, serum uric acid may be utilized as a predictor of death and morbidity as well as a measure of the severity of the illness. This report suggests more research on a wide foundation for verifying the observations.