International Journal of Medical and Pharmaceutical Research
2025, Volume-6, Issue-3 doi: 10.5281/zenodo.15686786
Case Report
BACLOFEN INDUCED ENCEPHALOPATHY – A Study of two cases with review of literature
Published
June 2, 2025
Abstract

Baclofen ,a centrally acting muscle relaxant is used for the treatment of spasticity, muscle spasms and intractable hiccups. Its main route of excretion is urine , therefore the drug gets accumulated in patients with chronic kidney disease resulting in toxicity. We report two cases of chronic kidney disease who developed encephalopathy with baclofen and improved after stopping the drug, spontaneously in the first patient and after two sessions of dialysis in the second case.

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