Association between high sensitivity C-Reactive protein and glycatedhemoglobin in patients with Type 2 Diabetes Mellitus

doi:10.5281/zenodo.7792305

International Journal of Medical and Pharmaceutical Research

2023, Volume-4, Issue-2 doi: 10.5281/zenodo.7792305

Original Article

Association between high sensitivity C-Reactive protein and glycatedhemoglobin in patients with Type 2 Diabetes Mellitus

Lakshmi Deepika Yarlagadda

Rohit Kumar Bonthapally

DOI : 10.5281/zenodo.7792305

Published

April 2, 2023

Abstract

Background: Hyperglycemia is considered an inflammatory condition. Among several markers of inflammation, hs-CRP (high sensitive C-reactive protein) takes a front seat in people with diabetes. So we conducted this study to find the association between hs-CRP and HbA1c(glycatedhemoglobin) levels in type 2 diabetics. Methods: This is a retrospective study of 70 (Males=42, Females=28) type 2 diabetic patients in NIMS (Nizam’s Institute of medical sciences) hospital, Hyderabad, India. We divided the patients into two groups based on their HbA1c levels (HbA1c <53 mmol/mol [7%]- well controlled [group1] and >53 mmol/mol [7%] – poorly controlled [group2] and compared hs-CRP levels between the two groups. Mann Whitney U testand Spearman correlation were performed. p-value<0.05 was considered significant. Results: Median(Range) for hs-CRP in group1 is 1.5mg/L( 0.1-7.6) and for group 2 poorly controlled group is 6.2mg/L(1.3-118).We found a statistically significant difference in hs-CRP between the two groups (p=0.0008). We also found a positive correlation between hs-CRP and HbA1c. Conclusion: In this study, hs-CRP levels positively correlated with HbA1C levels in type 2 diabetic patients.

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