Background: Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease that affects children and adults. It requires continuous insulin administration for glucose control. T1DM significantly impacts children's quality of life (QOL), affecting their daily activities and causing emotional and social challenges. Aim: The current study aims to assess the effect of Type 1 DM on the quality of life of children who seek treatment for the disease. Methodology: This cross-sectional study included 60 children with Type 1 Diabetes Mellitus (T1DM) divided into two age groups. The Pediatric Quality of Life Inventory (PedsQL) questionnaire assessed their quality of life from Physical, Emotional, Social and Schooling dimensions. Results: The study on children with Type 1 Diabetes Mellitus (T1DM) aimed to examine the differences in quality of life based on age and gender. The participants were divided into two age groups: 8-12 years and 13-18 years, with most children falling into the 8-12 years category. Male children constituted a higher proportion compared to females. Significant differences were found between the age groups across various dimensions of quality of life, with the 8-12 years group generally reporting higher scores. However, no significant gender differences were observed. Children with T1DM face physical, emotional, social, and schooling challenges, indicating the condition's impact on their lives. Conclusion: This study emphasizes the multidimensional impact of T1DM on children's quality of life and suggests targeted interventions. By addressing these multidimensional factors, we can better meet the needs of children with T1DM and improve their overall well- being.