Background & Aim: Frailty is a major prognostic factor in cirrhosis. Its assessment and intervention towards performance enhancement is important in the management of cirrhosis. Our study aimed to assess the prevalence of frailty in patients with cirrhosis and comparison of frailty by different indices.

Methods: One hundred and twenty cirrhotic patients were included. Frailty assessment was done using compares Fried frailty index (FFI), Clinical frailty index (CFI), Short physical performance battery (SPPB), Edmonton frail scale (EFS), Liver Frailty Index (LFI), ECOG, Karnofsky performance scale (KPS), and Instrumental activity of daily living (IADL). Risk factors of frailty analysis were made based on LFI.

Results: Mean age of presentation was 43.57±10.16years, and 80% were males. Most common etiology was alcohol (50.1%). Prevalence of frailty based on LFI, FFI, CFI, SPPB, EFS, ECOG, KPS, and IADL was 45%, 38.3%, 39.2%, 46.7%, 45%, 36.7%, 36.7%, and 29.2%. There was a significant positive association of frailty based on the LFI score with other scores (P<0.0001). Risk factors for frailty were being underweight (50% vs. 15%; P<0.0001), severity of ascites (P<0.0001), CTP score (P<0.0001), Mean MELD score (18.33±4.33 vs. 14.37±3.49; P<0.001) and MELD Na (20.43±4.62 vs. 15.50±3.95; P<0.001) was significantly higher among frails compared to non-frail patients.

Conclusions: Frailty is quite prevalent in liver cirrhosis. Frailty assessment should be routinely carried out. Frailty assessment by any score can be used to prevent further complications in these patients.