Objectives: This is a Case Series of 3 patients of APLS with varied presentations who were diagnosed and improved following treatment. Antiphospholipid antibody syndrome is a heterogenous autoantibody mediated acquired thrombophilia, which is associated with severe life-threatening complications during pregnancy.

CASES: Case 1: A 29 yr old female presented to us with Generalised edema over body and shortness of breath over the past 2 months, with severe anemia and a history of 2 pregnancy losses at 4 weeks and at 10 weeks of pregnancy. On evaluation, she was diagnosed as SLE with Class V Lupus Nephritis and Secondary APLS.

Case 2: A 35 yr old female presented with multiple episodes of GTCS, had a history of 3 abortions at 4, 6 and 10 weeks of pregnancy, and had an episode of Left sided Hemiparesis 2 years back. MRI was suggestive of chronic venous infarcts and she was diagnosed as a case of Primary APLS.

Case 3: A 20 yr old primigravida presented with Antepartum eclampsia, she suffered from an Intrauterine Death and post LSCS, she developed sudden onset weakness of Left side of her body. On evaluation for hypercoagulable state, was diagnosed with APLS.

Results and Conclusions: Clinicians should have a high index of suspicion of APLS in patients with history of recurrent abortions or Intra uterine death with unexplained cause.