Background- Acquired Immunodeficiency Syndrome (AIDS) is a disease of the human immune system caused by the Human Immunodeficiency Virus (HIV). This condition progressively reduces the effectiveness of the immune system and leaves individuals susceptible to opportunistic infections and tumors. Current ART regimens are capable of reducing viral load to undetectable levels with a consequent increase in CD4+ counts and a substantial reduction in HIV-associated morbidity and mortality. In spite of ART benefits, adverse reactions to these drugs have been pointed to as one of the main reasons for discontinuation and non-adherence to ART. Continuous evaluation of the benefit and harm of ART will help to achieve the ultimate goal of making safer and more effective treatment available to patients. Objective- This study is being undertaken to analyse the clinical profile of various adverse drugs reactions due to antiretroviral therapy among HIV positive patients. Methods- This is a prospective study conducted at Vijayanagar Institute of Medical Sciences Hospital, Ballari, period from February 2021 to August 2022. The participants were followed up at ART Plus Centre, and VIMS Hospital, Ballari for a total duration of 18 months. Relevant investigations were done to confirm the adverse reactions. Results- Among 115 patients enrolled for the study the largest no. of patients was in the age group of 31-40 years (33.91%), followed by 21-30 years (23.48%). In the current study, out of 115 study participants, majority were female (59.13%) and male participants were 47(40.87%). Conclusion- Antiretroviral therapy is becoming increasingly effective but also increasingly complex. The many adverse effects of therapy may cause symptoms affecting a variety of organ systems. Although current antiretroviral regimens are potent from an antiviral perspective, they often fail because of patient nonadherence.