Introduction: A vocal cord nodule (Singer’s or screamer’s or preacher’s nodes) is a common laryngeal benign lesion and also a common cause of hoarseness of voice in adults. A common space shared by Anesthesiologist in view of airway management and surgeons in view of excision or biopsy for vocal cord nodules. Objective: Describe the Airway management with advantages of Microlaryngeal Tracheal Tube in Vocal Cord Nodules. Method: A literature review was conducted using databases such as PubMed, Elsevier, and Google Scholar to identify relevant studies comparing Microlaryngeal Tracheal Tube with Portex Endotracheal Tube in Vocal Cord Nodule biopsy or excision. Result: We present a case of 63 years old male with Vocal Cord Nodule who underwentVocal Cord Nodule biopsy or excision under General Anesthesia using a Microlaryngeal Tracheal Tube for airway management. Conclusion: This case report highlights the superiority of Microlaryngeal Tracheal Tube (MLT) for airway management allowing better visibility and access to the surgical site.