Background: Migraine is a common neurological disorder often associated with psychiatric comorbidities, particularly mood disorders such as depression and anxiety. This study aims to evaluate the clinical correlation between migraine and mood disorders.

Methods: A prospective observational study was conducted on 84 patients diagnosed with migraine (based on ICHD-3 criteria). Participants were assessed for mood disorders using the Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS). Migraine severity, frequency, and disability were measured using the Migraine Disability Assessment (MIDAS) questionnaire. Statistical analysis was performed using Pearson’s correlation and chi-square tests.

Results: Among 84 participants (mean age 35.2 ± 9.4 years, 68% female), 52.4% (n=44) exhibited clinically significant depressive symptoms (HDRS ≥ 8), while 45.2% (n=38) had anxiety symptoms (HARS ≥ 10). A strong positive correlation was found between migraine frequency and depression severity (r = 0.62, p < 0.001). Patients with chronic migraine (≥15 headache days/month) had higher depression and anxiety scores compared to episodic migraine sufferers (p < 0.01).

Conclusion: This study demonstrates a significant correlation between migraine and mood disorders, suggesting that migraineurs are at higher risk of developing depression and anxiety. Early screening and integrated treatment approaches may improve clinical outcomes