Introduction: Several studies identified a link between gastroesophageal reflux disease (GERD) andobstructive sleep apnea (OSA). GERD is a condition in which acid reflux from the stomach to theoesophaguscauses troublesome symptoms. On the other hand, OSA is defined as a sleep-related breathing disorder inwhich airflow significantly decreases or ceases due to upper airway obstruction, leading to arousal fromsleep. OSA was found to be associated with GERD. In this study ,we aim to analyse the association of H.pylori infection in patients of obstructive sleep apnea presenting with symptoms of GERD . Methods:40 patients with symptoms of obstructive sleep apnea and gastroesophageal reflux diseases were enrolled . They underwent polysomnography and esophageogastroduodenoscopy .biopsy samples were taken and sent for histopathological examination with giemsa stain . Results: Out of 40 patients, 34 patients have giemsa positive h.pylori gastritis on biopsy (p=0.001)prevalence of h.pylori infection increases with severity of obstructive sleep apnea. Inmoderate osa (17.65%) , severe osa ( 82.35%)( p=0.004) Conclusion: This study concludes that there is significant association of h.pylori infection with OSA presenting with symptoms of GERD. Also, prevalence of h. pylori infection increases with severity of OSA.