Background: Sexually Transmitted Infections (STIs) have a deep impact on sexual and reproductive health. Among 27 million pregnant females each year, the prevalence of STIs are higher because of hormonal and immunological changes during pregnancy. STIs in pregnancy are usually under diagnosed and is a crucial reason behind morbidity and mortality within the developing countries. So, whenever an infection occurs in pregnancy, an understanding of the alteration within the disease course and also the possibility of transmission to the fetus is vital. Objectives: The present study was conducted to know about the different types of STIs in pregnant women attending our STI clinic in a tertiary care centre in South India over a period of 18 months. Methodology: A cross sectional study was conducted with a detailed history, clinical examination and relevant investigations in 110 pregnant women and data were analysed. Results: Among 110 subjects, Vulvovaginal candidiasis was more common with 50(45.5%) cases, followed by 36(32.7%) sero-syphilis in this study. 9(8.2%) were HIV reactive and 1(0.9%) had Hepatitis-B infection.