Aims and objectives: 1) To compare and correlate the result of FNAC with histopathological examination in diagnosis of thyroid lesions . 2) To define the role of FNAC in differentiating between benign and malignant lesions. Materials and methods: A prospective study carried out at a tertiary care centre. All patients with thyroid enlargement visiting the ENT department for a duration of 18 months were included in the study. Histopathological examination of the tumor could be done only in operated patients. Correlation of FNAC with histopathological examination will be done in those patients. Inclusion Criteria: Those patients with thyroid swelling, who underwent FNAC, Thyroid surgery and histopathological examination within the study period will be included in the study Exclusion Criteria: All the cases of thyroditis will be excluded. Those patients having FNAC done and did not have thyroid surgery and underwent medical management will be excluded. Results: 27 subjects showing anterior neck swelling, 23 subjects were female (85.2%) and 4 were male (14.8%). When FNAC based diagnosis was compared with Gold standard Histopathology Diagnosis, it was found that True positive cases were 3. There were no False positive cases. 21 cases were true negative whereas 3 cases came false negative. Conclusion: FNAC provides a more rapid and accurate diagnosis of thyroid lesions than any other combination of diagnostic test, however Histopathology is always required to confirm the diagnosis and for further management