International Journal of Medical and Pharmaceutical Research
2023, Volume-4, Issue-4 doi: 10.5281/zenodo.12781492
Original Research Article
A Histomorphological and Immunohistochemical Study of Malignant Nodal Lymphomas
Published
Feb. 4, 2025
Abstract

Background: Lymphomas are malignant clonal neoplasms of lymphocytes and their precursor forms. They are mainly of two types – non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). Incidence of lymphomas, especially NHL is increasing worldwide and also in India, therefore morbidity due to the disease is also increasing. Thus, knowledge of its pathogenesis, histomorphology and immunophenotype will lead to possible early diagnosis and treatment of this potentially curable disease. In this background, a study has been conducted. Objective: 1) To study the histomorphological features of malignant nodallymphomas. 2) To evaluate the expression of a panel of immunohistochemical markers for categorisation of nodal malignant lymphomas and theirsubtypes. Methods:A study was conducted for a period of 6 and a half years from January 2012 to June 2018 at the Department of Pathology, ESIC Medical College and PGIMSR with a sample size of 75 cases. All the cases diagnosed as nodal lymphomas during that period, were included in the study. Immunohistochemistry (IHC) was performed. Data was compiled onto a masterchart and descriptive statistics performed. Results: Majority patients presented with cervical lymphadenopathy. NHL was morecommon than HL among nodal lymphomas. Among NHL, diffuse large B cell lymphoma was the most common.AmongHL,nodularsclerosiswasthemostcommonsubtype.BothHLandNHLhad a male predominance. The mean age in HL was lower than that inNHL. Interpretation and Conclusion: Clinicopathological correlation and a goodhistomorphological diagnosis,supplementedbyimmunohistochemistrywillenableefficientdiagnosisofmaligna nt nodal lymphomas, and enable application of targeted therapyoptions

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