Cerebral palsy (CP) is a multifaceted neurodevelopmental disorder affecting motor functions and associated domains. This study explores the correlation between the Gross Motor Function Classification System (GMFCS), Gross Motor Function Measure (GMFM), and Manual Ability Classification System (MACS) in children with CP across Eastern Uttar Pradesh. A total of 2,139 children aged 2–18 years were evaluated using standardized tools. Results demonstrated significant correlations between functional classifications and measures, highlighting progressive declines in self-care abilities with increasing GMFCS levels. These findings underline the importance of integrated assessments to guide personalized interventions and improve care outcomes.