Nasal obstruction is one of the most common complaints in patients attending Otorhinolaryngology outdoor. The most common cause of nasal obstruction is deviated nasal septum [1]. Apart from nasal obstruction, a significantly deviated nasal septum has been implicated in epistaxis, sinusitis, obstructive sleep apnea headache and otitis media [1-3]. Septoplasty is a surgical procedure used to correct a deviated nasal septum and its one of the commonly performed. Nasal packing after nasal septal surgery has been practiced for decades to prevent post-operative bleeding, septal hematoma pain and discomfort likes epiphora, sleep disturbance, headache and dryness of mouth that the patient has to undergo in the 48 hours post operatively. Aim & Objectives: To compare the intra-operative and post-operative outcome of trans-septal suture and nasal packing performed during Septoplasty. Materials and Methods: A Cross sectional observational study was taken up in the Department of Otorhinolaryngology, Head & Neck Surgery, Agartala Government Medical College & GBP Hospital in 78 patients with DNS underwent septoplasty surgery. Results: Amongst the patients who underwent Trans-septal suturing none of the patients reported Epiphora, Headache or dryness of mouth. Only 1 (2.6%) patient each reported sleep disturbance, post operative bleeding or synechia. Whereas All the patients who underwent Nasal packing reported Epiphora and Headache, 31 (79.5%) patients reported sleep disturbance whereas 38 (97.4%) reported dryness of mouth, 28 (71.8%) reported pain on pack removal, 2 (5.1%) reported post operative bleeding whereas synechia was seen in 1 (2.6%) patient.