Background: Chronic non-healing ulcers frequently lead to hospital admissions in surgical wards. Despite identifying the underlying cause, such ulcers pose treatment challenges due to factors like diabetes mellitus and infection. The present study aimed to investigate the clinical outcomes of vacuum-assisted wound dressing compared to conventional saline dressing in non-healing ulcers. Materials & Methods: This hospital-based randomized controlled study was conducted among patients aged over 18 years with non-healing ulcers persisting for more than three weeks, admitted to the inpatient services of the Department of General Surgery,Karpaga vinayaka institute of medical science Chengalpettu over an 18-month period. Patients with complete necrosis, bleeding disorders, malignant ulcers, abdominal wounds, and electrical burns were excluded. Patients were allocated into two groups based on intervention: Group A received vacuum-assisted dressing, while Group B received conventional saline dressing. Patients were evaluated for wound healing rate, granulation tissue formation, culture reports, and total duration of hospital stay. Results: A total of 66 patients were included, with a mean age of 54.63 ± 9.36 years, comprising an equal distribution of male and female participants. There were no significant differences in demographic details between the groups (p > 0.05). The study revealed a significantly higher wound healing rate in patients of Group A compared to those in Group B (p < 0.05). Similarly, pus culture sterilization and shorter hospital stays were significantly better in Group A compared to Group B (p < 0.05). Conclusion: Vacuum-assisted dressing led to reduced overall hospital stays, improved pus culture sterilization, and exhibited better wound healing rates and granulation tissue formation compared to conventional dressing for non-healing ulcers. Keywords: Dressing, Vacuum-Assisted, Conventional, Complication, Ulcer, Wound Closure.