This case report details a 38-year-old male presenting with symptoms including muscle twitching, cramps, and bilateral ptosis. He was diagnosed with neuromyotonia (Isaacs syndrome) alongside myasthenia gravis (MG), indicated by the presence of serum acetylcholine receptor (AChR) antibodies. The patient showed significant improvement after a 5-day course of intravenous methylprednisolone and phenytoin administration. This case suggests overlapping pathophysiological mechanisms between neuromyotonia and autoimmune myasthenia gravis, warranting further research.