Introduction: Caesarean section is probably the most common surgical procedure carried out in obstetrics. The rates of caesarean sections have risen steadily in the past few decades. Caesarean section in the second stage of labour is a more challenging surgical procedure and has adverse feto-maternal outcomes than performed in the first stage or before labour. The present study was done at our tertiary care centre to compare complications of Caesarean Section in the First Stage and Second Stage of Labour and the strategy to reduce maternal and neonatal complications. Objective: To study the indications of first stage of LSCS and second stage of LSCS and to study Maternal and neonatal outcome in first stage and second stage of LSCS. Methods: Prospective observational study in tertiary institute from November 2020 to October2022 in department of OBGY, GMCH, Aurangabad, Maharashtra. Institutional Ethical committee approval was taken. 200 women willing to participate in the study are chosen as per the inclusion and exclusion criteria. Among these 100 women of first stage LSCS and 100 women of second stage LSCS. Results: In present study, most of women were unbooked (62.5%) and from rural area (58%),belongs to 21-25 years age group (55.5%) and 53% had normal BMI range (>18-25) with 54% had socio-economic class IV. As compare to first stage, Second stage LSCS had more intraoperative and postoperative maternal complications like excessive blood loss (P value 0.035)., uterine artery ligation (P value<0.001), extension of uterine incision (P value 0.009), blood transfusion requirement (P value 0.017), more operative time(P value0.006), prolonged hospital stay(Pvalue0.004).In Neonatal outcomes, NICU admission were more in second stage LSCS than first stage LSCS. Conclusion: Second stage LSCS has significant neonatal morbidities as well as maternal morbidities. The rate of complications of second stage LSCS can be minimized by use of partograph in labour, consistent monitoring of labour and timely intervention and it should be handled and operated by experienced obstetricians.