This study aimed to predict atherosclerosis in menopausal women based on independent variables such as age, diabetes mellitus (DM), hypertension (HTN), and body mass index (BMI). A total of 105 postmenopausal women attending the gynaecology outpatient department at SMS Medical College, Jaipur, were included in this observational study. Carotid intima-media thickness (cIMT) was measured using ultrasound to assess subclinical atherosclerosis. The results indicated that age, DM, HTN, and BMI were significant predictors of increased cIMT. Women with higher BMI, diabetes, and hypertension had significantly greater cIMT values, suggesting a higher risk of atherosclerosis. This study highlights the importance of early screening and management of these risk factors to prevent cardiovascular diseases in menopausal women.