International Journal of
Medical and Pharmaceutical
Research

 Why us?


 Open Access
 Peer-reviewed
 Rapid publication
 Lifetime hosting
 Free indexing service
 Free promotion service
 More citations
 Search engine friendly
Role of Platelet Indices in Patients With Thrombocytopenia in Serologically Positive Dengue Patients
Dr Snehal Eknath Karanjekar, Dr Shivani Battin, Dr Gauri Kelkar, Dr Shreya Pawaskar, Dr Surekha Kadadi, Dr Rashmi Vanjari
DOI : 10.5281/zenodo.7811880
Download PDF
Abstract

Background: Dengue fever (DENV) is one of the most rapidly spreading mosquito-borne viral diseases in the world. An estimated 50 million infections per year occur across approximately 100 countries. 30 fold increased incidence and geographic expansion with potential for further spread has been noted. Platelet count is a predictive prognostic factor of severe dengue. Besides platelet count, automation in haematology has provided newer parameters i.e., platelet indices like Plateletcrit (PCT), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Large Cell Count (P-LCC) and Platelet Large Cell Ratio (P-LCR). This study aims to analyse the relationship of platelet indices in thrombocytopenic dengue patients thus helping clinicians by providing quick and reliable diagnostic and prognostic findings. Objective: To analyse the relationship of platelet indices in thrombocytopenic dengue patients. Materials and Methods: A cross sectional, observational study at a tertiary health care centre over a period of 2 years including 113 dengue cases presenting with thrombocytopenia. Thrombocytopenia was graded according to platelet count per ml as Grade 1 (75,000-1,50,000), Grade 2 (50,000-75,000), Grade 3 (25,000-50,000) and Grade 4 (<25,000). Results: In this study of 113 cases, maximum cases (46.9%) were seen in 21-30 year age group followed by 11-20 year age group (15.04%). Least number of cases belonged to 61-70 year age group (2.65%). 81 were males and 32 were females. Most common presenting symptom was headache (58.40%). The other symptoms were body ache (46.90%), arthralgia (27.43%) and maculopapular rash(32.74%). A total 50 cases (44.25%) shows grade 2 thrombocytopenia, 31 cases (27.43%) show grade 3 thrombocytopenia and 13 cases (11.50%) show grade 4 . The Mean values of the Platelet indices were as follows: Mean Platelet Volume (MPV)= 6.43 fL which was less than normal limit (8-11 fL); Platelet Distribution Width (PDW) = 19.67% which was greater than normal range of 11-18%; Plateletcrit (PCT) = 0.05which was near the lower limit of laboratory reference range; Platelet Large Cell Count (PLCC) = 35.68 x 103/ul which was lower than normal range 44-140 x 103/ul; Platelet Large Cell Ratio (PLCR) = 32.35 % which was within laboratory reference range of 18-50%. Conclusion: In conclusion, significant differences i.e., Low platelet count, MPV, PCT, PLCC and high PDW, observed in dengue fever with thrombocytopenia can be used as a diagnostic aid with considerable sensitivity for dengue fever in endemic areas.

Follow Us


About Us


IJMPR is an international open access source for a high quality and peer reviewed journal in the fields of Medical and Pharmaceutical Sciences. IJMPR publishes research papers across all academic disciplines in the fields of Medical, Pharmaceutical Sciences.

Contact Us


editor@ijmpr.in
Copyright © 2023 | IJMPR | All Rights Reserved

Versicherungsvergleich

A PHP Error was encountered

Severity: Notice

Message: fwrite(): write of 34 bytes failed with errno=122 Disk quota exceeded

Filename: drivers/Session_files_driver.php

Line Number: 267

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/cpanel/php/sessions/ea-php74)

Filename: Unknown

Line Number: 0

Backtrace: