Introduction: Dengue virus causes a spectrum of illness ranging from in apparent, self-limiting classical dengue fever (DF) to life threatening dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Present study is done to identify the clinical profile, hematological profile and disease outcome in dengue fever cases. Methods: A total of120 cases aging 18 to 80 years diagnosed as dengue fever based on rapid immunological card test (Ns1 antigen, IgG and IgM antibodies) were analysed for clinical and hematological parameters. A prospective observational study was conducted at HIMS, Hassan. Result: During the study period, a total of 120 dengue cases were included in the study. Of these61%male, 39%female.NS1 antigen positive 35(29%), IGM 50%positive was being highest and IGG 21%.The most common presentation was fever (100%) followed by myalgia (75%),retro orbital pain and vomiting (33%).The common hematological finding was thrombocytopenia 81(67.5%),followed by anemia66(55%), leucopenia39(39%) and the elevated levels of AST and ALT was noted. Conclusion: Thrombocytopenia, leucopenia, elevated AST and ALT gives clues to test dengue fever so that the dengue cases can be identified in early stages and prompt management can be started to prevent complications.