Purpose: This study aimed to investigate the prevalence of musculoskeletal problems among salesmen in Dhaka, Bangladesh, and explore the socio-demographic factors associated with these issues. Objective: The objectives were to assess the socio-demographic characteristics of the salesman population, identify the prevalence of neck and low back pain, examine symptom notifications, and evaluate the association between working hours and musculoskeletal problems. Background: Musculoskeletal problems, including pain in the neck and low back, are common occupational health issues, particularly among individuals with physically demanding jobs. Salesmen, who often engage in prolonged standing and lifting activities, are at risk of developing such problems. Methodology: This cross-sectional descriptive study involved 200 salesmen in Dhaka. Data was collected using a modified questionnaire, and statistical analysis was performed using SPSS software. Numerical coding facilitated data entry, and graphs were created in Microsoft Excel 2019. The chi-square test determined the significance of relationships. Result: The study found that 9.5% of participants experienced neck pain, 1.5% had shoulder pain, 0.5% reported wrist pain, 8.5% suffered from back pain, 46.0% encountered hip pain, 16.5% faced knee pain, and 20.0% experienced ankle pain. There was no significant association between age and pain in any body part (p= 0.124). Similarly, no significant relationship was observed between sex and pain severity (p= 0.95). Conclusion: From the study it can be concluded that the most affected age range is 24 to 30 years for musculoskeletal pain developed some factor such as physical activity, posture. So, increase awareness most important and physiotherapy treatment will give the affected participants which ultimately help them for pain.