Systemic review and meta-analysis of grey lesions in breast pathology.The current systematic review & meta-analysis adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, making sure that reporting is rigorous and transparent. Our search strategy focused on identifying relevant studies published between May 2020 and May 2021, with an emphasis on English language articles. Medline was systematically queried, and an extensive search of the PubMed Central (PMC) literature was conducted to pinpoint journal articles featuring both FNAC and HPE comparisons. Particularly in a situation where resources are limited, this systematic review and meta-analysis that compares the effectiveness of Fine Needle Aspiration Cytology (FNAC) against Histopathological Examination (HPE) is unique. FNAC exhibits substantial predictability in identifying malignancies within the grey zone of breast lesions, reinforcing its efficacy in resource-limited settings.