Background: Fine needle aspiration cytology is a rapid, economical and minimally invasive technique without substantial complications for the diagnosis of benign and malignant lesion. The aim of present study was to evaluate the nature of space occupying lesion in liver (hepatic mass) by FNAC under ultrasound guidance as well as to assess the demographic spectrum of the patients. Material and Methods: A total of 234 cases presenting with space occupying lesion of liver were included in the study. Ultrasound guidance FNAC was performed from the sol liver in the presence of trained radiologist using 20-22 gauze disposable spinal needle connected to 10 ml disposable plastic syringe with full aseptic precautions. Results: The minimum and maximum age of the patients was 6 years and 89 years respectively. However, the mean age of the patient was 54 years with mean ± SD as (54±16 yrs.). Among the females, 75.4% were above the 40 years of age and whereas, 78.6% males were above 40 years of age. A highly statistically significant difference (p<0.0001) was found for age greater than 40 years for all categories of disease when compared to age less than 40 years. Occurrences of primary (84.3%), secondary (83.5%) and other (85.7%) malignancies were significantly (p <0.001) higher in patients aged above 40 years. Secondary malignancies, metastatic adenocarcinoma (50.0%) was the most common malignancy causing space occupying lesion of liver, followed by primary malignancy of liver (38.46%). Other malignancies were seen in (11.54%) cases. 7 cases (2.99%) were diagnosed as suspicious for malignant due to hypo cellular smear consisting of few atypical cells and 11 cases (4.70%) were non representative (inconclusive), as it contained only few scattered hepatocytes in the background of RBCs. Conclusion: Ultrasound guided FNAC from space occupying lesion of liver is highly accurate technique for making the diagnosis of hepatic lesions without any major complications and can accurately distinguish non-neoplastic lesions from neoplastic lesions as well as categorize primary and secondary malignancies, helping in management of hepatic lesions.