Ayurveda, or the science of life, takes a holistic approach to healthy living. It discusses the physiology and pathology of diseases, as well as their treatments. Several diseases have been treated with plant extracts based on traditional medicine since ancient times. Cyperus rotundus L. (Cyperaceae family) is a colonial, perennial herb. As science and cutting-edge technologies advanced, different herbal extracts and chemical constituents of herbs were identified as therapeutic targets. Cyperus rotundus, also known as mustaka, is an ancient herb found in tropical and subtropical regions around the world. The tuberous and aerial parts of the herb have been found to have a variety of pharmacological properties. The synergistic actions of the Cyperus compounds provide an advantage over a single compound.